This is a question I hear often, from those in despair, from those who have tried and failed, from those who have tried and succeeded and realised that the goals they once wanted do not satisfy.
The question may sound like the end of hope, but to me it's a great question, it signifies the beginning. The beginning of some of the most important questions we will ever ask; 'Who am I?' and 'What do I want/need?' You may be surprised by the answers you find.